Role of interleukin 33 in chronic rhinosinusitis
نویسندگان
چکیده
منابع مشابه
The role of interleukin-33 in chronic allergic conjunctivitis.
PURPOSE The authors discovered a genetic association between the ST2L gene and atopy. The ST2L gene encodes a membrane-bound functional marker for Th2 cells. Recently, a novel Th2 cytokine, interleukin-33 (IL-33), was discovered to be a specific ligand for ST2L. The authors investigated the role of IL-33 in chronic allergic conjunctivitis. METHODS Immunohistochemical analysis was carried out ...
متن کاملThe Role of Interleukin-33 in Rhinitis
IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine ...
متن کاملInterleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis
Introduction: IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2 +1208 C/T genes ...
متن کاملThe role of fungi in chronic rhinosinusitis.
Collective clinical and bench observations of the past 25 years have expanded interest in the role that fungi may play in developing and perpetuating inflammatory disease of the respiratory tract. As with any new concept, controversy regarding such a process has emerged, but it has served to stimulate increased interest and further study. Review of the current literature appears to offer strong...
متن کاملRole of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps
BACKGROUND AND OBJECTIVES Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. The dysregulation of IL-10 is associated with an enhanced immunopathologic response to infection, as well as with an increased risk for developing numerous autoimmune diseases. In this study, we investigated IL-10 expression in chronic rhinosinusitis with nasal polyps (CRSwNP) and assessed the possible role...
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ژورنال
عنوان ژورنال: Thorax
سال: 2017
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2016-209655